podosome meaning in Hindi

Examples

1. A podosome consists of a core rich in actin surrounded by adhesion and scaffolding proteins.
2. Typically, the podosome size falls between 0.5 um and 2.0 um in diameter and depth.
3. As an important actin regulator, gelsolin plays a role in podosome formation ( along with Arp3, cortactin, and Rho GTPases ).
4. Inhibition of bone resorption through drug intervention results in the lack of the podosome band during early osteoclast differentiation and ultimate absence of a sealing zone.
5. Plasma membranes can also form different types of " supramembrane " structures such as caveola, postsynaptic density, podosome, invadopodium, desmosome, hemidesmosome, focal adhesion, and cell junctions.
6. These finding were made possible through the application of Bayesian blinking and bleaching analytics to data gained from standard widefield microscopy using cells that expressed fluorescently tagged proteins specific to the podosome ring complex.
7. WASp is required for various functions in myeloid and lymphoid immune cells, Many of these, such as phagocytosis and podosome formation, related to its role in regulating the polymerization of actin filaments.
8. SU6656 was initially identified as a Src kinase inhibitor by virtue of its ability to reverse an effect that an activated mutant form of Src ( hu SRC Y530F ) has on the actin cytoskeleton, namely the formation of podosome rosettes, otherwise known as invadopodia.
9. To distinguish podosomes from others types of cellular adhesions, the protein Tks5 and WASP ( Wiskott-Aldrich Syndrome protein ) are used as markers alongside actin, cortactin and the Arp2 / 3 complex to localize and isolate these protrusions because Tks5 and WASP are unique to the podosome when compared with other actin-based cellular structures.