the thing is in a sentence

Examples

1. But unfortunately the thing is that we don't understand metabolism very well.
   दुर्भाग्यतापूर्ण बात यह है कि हम चयापचय को बहुत अच्छी तरह समझते नहीं हैं.
2. Because, the thing is,
   क्योंकि, मुद्दा ये है,