norethisterone in a sentence
Examples
- A 2001 comparative study of the IMS LifeLink Health Plan Claims Database interpreted that in a large cohort of women using oral contraceptives, there was found a small, statistically significant increase in the risk of gallbladder disease associated with desogestrel, drospirenone and norethisterone compared with levonorgestrel.
- In addition, the testosterone analogue of 19-norprogesterone, 19-nortestosterone ( also known as nandrolone ), is an anabolic-androgenic steroid ( AAS ) and progestogen, and is the parent compound of a large group of AAS and progestins that includes norethisterone.
- However, androgenic progestins, such as 19-nortestosterone derivatives like norethisterone and levonorgestrel and others like, to a lesser extent, medroxyprogesterone acetate ( MPA ), when taken orally, induce IGF-1 production via activation of the androgen receptor ( AR ) in the liver.
- Noretynodrel, an isomer of norethisterone, was synthesized in 1952 by Frank B . Colton at Searle in Skokie, Illinois and used as the progestin in " Enovid ", marketed in the U . S . in 1957 and approved as the first oral contraceptive in 1960.
- The results of his small-scale trial ( on no more than 50 fertile married women ) led him to conclude that a dose of 3 to 4 mg of norethisterone acetate and'at least'0.05 mg of ethinylestradiol was both efficient and had few side effects.
- Alternatively, estranes such as noretynodrel and norethisterone are classified as first-generation while gonanes such as norgestrel and levonorgestrel are classified as second-generation, with less androgenic gonanes such as desogestrel, norgestimate, and gestodene classified as third-generation and newer progestins like drospirenone classified as fourth-generation.
- Among the testosterone derivatives, and in no particular order, levonorgestrel, norgestrel, norgestrienone, ethisterone, gestrinone, danazol, normethandrone, and norvinisterone have the greatest androgenic activity, while norethisterone and its prodrugs ( norethisterone acetate, norethisterone enanthate, lynestrenol, etynodiol diacetate, and quingestanol acetate ) have moderate activity.
- Among the testosterone derivatives, and in no particular order, levonorgestrel, norgestrel, norgestrienone, ethisterone, gestrinone, danazol, normethandrone, and norvinisterone have the greatest androgenic activity, while norethisterone and its prodrugs ( norethisterone acetate, norethisterone enanthate, lynestrenol, etynodiol diacetate, and quingestanol acetate ) have moderate activity.
- Among the testosterone derivatives, and in no particular order, levonorgestrel, norgestrel, norgestrienone, ethisterone, gestrinone, danazol, normethandrone, and norvinisterone have the greatest androgenic activity, while norethisterone and its prodrugs ( norethisterone acetate, norethisterone enanthate, lynestrenol, etynodiol diacetate, and quingestanol acetate ) have moderate activity.
- In terms of dosage equivalence, norethisterone and NETA are typically used at respective dosages of 0.35 mg / day and 0.6 mg / day as progestogen-only contraceptives, and at respective dosages of 0.5 1 mg / day and 1 1.5 mg / day in combination with ethinylestradiol.