idiotype meaning in Hindi

Examples

1. The word " idiotype " became influential in immunology when Niels Jerne formulated his immune network theory.
2. The engraved inner portions of idiotype ( encircled region no . 5 ) is the paratope where the epitope of the antigen binds.
3. He defined idiotype as the set of epitopes on the V region of an antibody molecule, where epitope means an antigenic determinant.
4. Cold agglutinins commonly have variable heavy-chain regions encoded by VH, with a distinct idiotype identified by the 9G4 rat murine monoclonal antibody.
5. The best developed version of immune network theory is called the symmetrical network theory, in which the distinction between idiotype and paratope plays no role.
6. Multiple other B cell antigens are being studied as targets, including CD22, CD23, ROR-1 and the immunoglobulin light-chain idiotype expressed by the individual cancer.
7. "' Abagovomab "'is a mouse anti-idiotype monoclonal antibody whose variable epitope mirrors a tumour antigen ( CA-125 ) highly expressed in the epithelial ovarian cancer.
8. So, when a full, high-fidelity copy of the idiotype is linked to a foreign protein ( KLH ), and administered with an immune-enhancing agent ( GM-CSF ), the resulting vaccine can mount a highly specific anti-lymphoma attack that  trains the body s own immune system to solely recognize the idiotype as a  foreign invader, thus stimulating and recruiting the patient s own immune system to destroy micro-pockets of cancer cells that may remain following chemotherapy and potentially target and destroy newly arising lymphoma cells, thus delaying or preventing cancer recurrence.
9. So, when a full, high-fidelity copy of the idiotype is linked to a foreign protein ( KLH ), and administered with an immune-enhancing agent ( GM-CSF ), the resulting vaccine can mount a highly specific anti-lymphoma attack that  trains the body s own immune system to solely recognize the idiotype as a  foreign invader, thus stimulating and recruiting the patient s own immune system to destroy micro-pockets of cancer cells that may remain following chemotherapy and potentially target and destroy newly arising lymphoma cells, thus delaying or preventing cancer recurrence.