anergic meaning in Hindi

Examples

1. Without signal 2, the T cell will not be activated, and will become anergic.
2. CD28 is the only MHC : antigen complex without CD28 : B7 interaction results in a T cell that is anergic.
3. This is because B cells need co-stimulatory signals from T cells as well as the presence of its recognized antigen to proliferate and produce anergic.
4. The second signal comes from co-stimulation, in which surface receptors on the APC are induced by a relatively small number of stimuli, usually products of pathogens, but sometimes breakdown products of cells, such as anergic, and it becomes more difficult for it to activate in future.
5. The response to antigen at this stage depends on the properties of the antigen, the cell type, and the developmental stage, and can lead to the cell becoming non-responsive ( anergic ), undergoing directed suicide ( negative selection ), altering its antigen receptor ( receptor editing ), or entering a regulatory lineage.
6. Cytotoxic T cells ( T C cells, CTLs, T-killer cells, killer T cells ) destroy virus-infected cells and tumor cells, and are also implicated in IL-10, adenosine, and other molecules secreted by regulatory T cells, the CD8 + cells can be inactivated to an anergic state, which prevents autoimmune diseases.